PROBIIOTIICS IIN DERMATOLOGY

Abstract

robiotics are defined as "live micro-organisms," which, when administered in adequate amounts confers a health benefit on the host''. They are – like normal microflora of the human GIT and skin - non-pathogenic microbes, which do not induce inflammatory responses. On the other hand, prebiotics are defined as ―a non-digestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon.‖ Both probiotics and prebiotics are together, synbiotics; improve the survival of the bacteria in the GIT, so that their effect is more. The human intestine harbors an enormously complex, diverse, and vast microbial community, referred to as gut microflora or microbiota. Any impairment of the GI microbiome, for example, by administration of oral antibiotics, or by an unbalanced diet will affect the functionality of the host‘s local defense systems. The human skin, as well, is covered with a continuous layer of microbes, which reside within epidermis, dermis, and the skin-associated glands and follicles, forming a diverse multi-cellular community known as the normal skin microbiota. The skin microbiota constitutes mainly of different bacteria but also of fungal species.