The Prognostic Role of Some Laboratory Biomarkers and Certain Clinical Scoring Systems in the Assessment of Brain Injury in Acute Carbon Monoxide Poisoning A Prospective Study Done on Acutely Carbon Monoxide Intoxicated Patients in Poison Control Center Ain Shams University Hospitals

Abstract

cute CO poisoning is one of the most common fatal poisonings worldwide. It causes tissue hypoxia producing various neurological and cardiological complications. CO-induced hypoxic brain injury can occur at varying degrees leading to vegetative state, development of NS or death. Although the diagnosis of CO poisoning is made by measuring COHb level. Yet, COHb levels are insufficient to determine the clinical severity of brain injury or prognosis. Thus, there is a need for an ideal biomarker that might be highly specific for brain injury, sensitive to minor injuries, appears rapidly in the serum and is easily measurable with rapidly obtainable results. The present study aimed at assessing the role of brain injury biomarkers: S100B, NSE and GFAP protein in early detection and evaluation of acute CO-induced brain injury and its consequences among acutely CO-intoxicated patients in PCC-ASUH. Also, evaluating and comparing the accuracy of APACHE II versus PSS in predicting the mortality outcome of acute CO- intoxicated patients and finally suggesting criteria for selection of patients candidate for HBOT. This study was conducted on 50 adult patients of both sexes presented to PCC-ASUH with acute CO poisoning during the period from beginning of November 2015 till the end of January 2017. The diagnosis of acute CO poisoning was A