Assessment of Urinary Growth Regulatory Alpha Protein in Type 1 Diabetic Children and Adolescents With and Without Microalbuminuria

Abstract

Diabetic microvascular complications are often asymptomatic during their early stages, and once symptoms develop, there is little to be done to cure them. Therefore, screening needs to be started early during adolescence. Renewed attention has been given to inflammatory markers as a new tool in early detection of renal diseases in patients with T1DM. This study aimed at estimating the degree of renal impairment in children and adolescents with T1DM with and without microalbuminuria, using urinary levels of GRO-α and estimated glomerular filtration rate measured by creatinine clearance to evaluate the renal function. The present study included 30 children and adolescents with T1DM for less than 5 years duration with normoalbuminuria and 30 children and adolescent with T1DM for more than 5 years duration with microalbuminuria in addition to 15 age- and sex-matched healthy controls, regularly