Protective effect of Nano zinc particles against renal cancer induction in rats

Abstract

Ferric-nitrilotriacetic acid (Fe-NTA) being one of the most potent iron pro-oxidant compounds which used in the present study to induce oxidative stress and induction renal carcinoma in rats. Nitrilotriacetic acid is a synthetic tricarboxylic acid which forms water soluble chelate complexes with various metal ions including iron at natural PH. Its iron complex Fe-NTA is a nephrotoxic agent. It induces apoptosis in rats' renal proximal tubules. The renal toxicity is assumed to be caused by the elevation of serum free iron concentration following its reduction at luminal side of proximal tubule generating ROS leading to enhancement of lipid peroxidation with a concomitant decrease in tissue glutathione level. Nanotechnology has provided a way for us to rearrange and restructure matter on an atomic scale, allowing us to reach down to the very roots of any problem. There is evidence that zinc is an effective antioxidant and investigated in clinical trials as a cancer chemo preventive agent. Therefore, the purpose of this study was to evaluate the protective effect of biosynthesized zinc nanoparticles (Zn- NPs) synthesized using edible white mushroom Agaricus bisporus against renal cancer induction in rats. To achieve Summary 164