RELATIONSHIP BETWEEN OXIDATIVE STRESS AND BEHAVIOUR DISORDERS AMONG ASTHMATIC CHILDREN

Abstract

Background: Paraoxonase-1 is a critical anti-oxidant enzyme to combat against oxidative stress and it has been involved in the pathogenesis of chronic diseases including bronchial asthma. As well as chronic illness it is clearly an important factor affecting psychosocial state of children and adolescents. Objective: This case-control study is an effort to explor the relation between oxidative stress and behavior changes among asthmatic children and to assess relation between asthma control and maintenance of positive physical and psychological wellbeing. Subjects and Methods: This study was executed in the Chest & allergy outpatient clinic in Pediatric hospital, Faculty of Medicine, Cairo university, over a period from April 2015 to June 2016. The Study was carried out on 60 children suffering from bronchial asthma (38 boys and 22 girls) with an age range of 6-12 years (mean age ± SD = 8.43±1.87). Thirty age and sex matched children not suffering from any disease and living under the same socioeconomic conditions were taken as controls. Patient group was subdivided into two equal groups (30 patients each): Controlled and Uncontrolled asthmatic groups. After detailed history taking and complete general and local examination of all participants, laboratory investigation (including total IgE, total oxidative capacity and paraoxonase-1), pulmonary function tests, Assessment of behavior by Pictorial Pediatric Symptom Checklist- 17 Score, and IQ by draw a person test were done. Results: plasma PON1, TOC, and IgE levels are related to the level of asthma control in children. We have also observed that the PON1 activity of the asthmatic children was lower than in the control group. Additionally, plasma IgE and TOC levels were significantly higher in asthmatic patient than controls. There was significant difference in the IQ between healthy and both controlled and uncontrolled asthmatic children. However, there was no significant difference observed in IQ scores between controlled and uncontrolled asthmatic patients. Patients have higher score of Pictorial Pediatric Symptom Checklist-17 (PPSC-17) compared to healthy controls with high statistically significant difference between them. With association between behavioral problems and asthma control levels. Conclusion: Our results indicated that chronic asthma disease has a negative effect on antioxidants status, cognitive abilities and psychosocial behavior of such children.