Ventilatory Bundle for Acute Respiratory Distress Syndrome

Abstract

• Since first described at World War I, Acute respiratory distress syndrome (ARDS) is a major subject for extensive studying for definition, identification and best possible management. Multiple serial ARDS definitions were being sought starting by Ashbaugh in 1967, followed by lung injury scoring system and American European consensus conference definition (AECC). • The most recent Berlin definition in 2012 maintains links between previous definitions and recent diagnostic criteria and patient outcomes. The revised definition appears to have improved predictive validity for mortality and spectrum of severity. According to this, ARDS was defined as an acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung tissue with hypoxemia and bilateral radiographic opacities, associated with increased venous admixture, increased physiological dead space and decreased lung compliance (Ranieri et al, 2012).