SOME BIOCHEMICAL MARKERS OF BONE TURN OVER IN PATIENTS WITH EARLY OSTEOPOROSIS
FATMA ABD EL- AAL ABO EL-WAFA;
Abstract
The present study was performed on 90 individuals categorized as follows:
- Twenty apparently health non-symptomatizing postmenopausal women as a control group with their age ranging from 48-59 years.
- Forty women suffering from generalized axial bone ache and at risk of being osteoporotic with their age ranging from 50-74 years.
- Thirty women with pathological fracture with there age ranging from
70-85 years.
- Urine samples were obtained from subjects as following:
a. First morning sample for detection of urinary deoxypridinoline cross links by solid phase chemiluminescent enzyme immunoassay.
b. 24 hours urine collection for detection of calcium in urine.
- Blood samples were obtained from fasting subjects and serum was separated.
- In addition to full history and clinical examination, all the studied individuals were subjected to the following investigations: FBS, prothrombine time, total protein, albumin, ALP, creatinine, urine calcium, ostescalcin and urine pyrilink (Dpd).
- In the control group the mean value± SD of urinary deoxypyridinolin level was 5.67 ± 1.12 nM DPD mM creatinine and the range was (4-7.3 nM OPD/ mM creatinine).
- Significantly elevated urinary DPD values were found in patients with postmenopausal osteoporosis.
- Significant elevated serum osteocalcin level was found in patients with
postmenopausal osteoporosis.
- Twenty apparently health non-symptomatizing postmenopausal women as a control group with their age ranging from 48-59 years.
- Forty women suffering from generalized axial bone ache and at risk of being osteoporotic with their age ranging from 50-74 years.
- Thirty women with pathological fracture with there age ranging from
70-85 years.
- Urine samples were obtained from subjects as following:
a. First morning sample for detection of urinary deoxypridinoline cross links by solid phase chemiluminescent enzyme immunoassay.
b. 24 hours urine collection for detection of calcium in urine.
- Blood samples were obtained from fasting subjects and serum was separated.
- In addition to full history and clinical examination, all the studied individuals were subjected to the following investigations: FBS, prothrombine time, total protein, albumin, ALP, creatinine, urine calcium, ostescalcin and urine pyrilink (Dpd).
- In the control group the mean value± SD of urinary deoxypyridinolin level was 5.67 ± 1.12 nM DPD mM creatinine and the range was (4-7.3 nM OPD/ mM creatinine).
- Significantly elevated urinary DPD values were found in patients with postmenopausal osteoporosis.
- Significant elevated serum osteocalcin level was found in patients with
postmenopausal osteoporosis.
Other data
| Title | SOME BIOCHEMICAL MARKERS OF BONE TURN OVER IN PATIENTS WITH EARLY OSTEOPOROSIS | Other Titles | دراسة بعض الدلالات البيوكيميائية لمعدل إحلال العظام في مرضي هشاشة العظام المبكرة | Authors | FATMA ABD EL- AAL ABO EL-WAFA | Issue Date | 2001 |
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