Evaluation of the Role of Prostaglandin E2in the Pathogenesis of Vitiligo
Asmaa Galal Elbadawy Taher Mohamed;
Abstract
Vitiligo is an acquired depigmentary disorder of the skin and mucous membranes, due to loss of cutaneous melanocytes or alteration in their function. It is characterized by circumscribed white macules and patches.
The main function of epidermal melanocytes is to synthesize melanin in response to UVR. Studies suggest that PGE2 plays an important role in melanogenesis. PGE2 stimulates melanocytes dendrite formation, tyrosinase activity, and proliferation in human melanocytes. Researchers got encouraging results when they used topical PGE2 for treatment of vitiligo.
Prostaglandins are synthesized from AA by COX enzymes. The COX enzyme family consists of two isoforms; COX-1 which is constitutively expressed and COX-2 which is inducible. It has been found that UVR-induced COX-2 expression plays a major role in PGE2 production. In the epidermis, both keratinocytes and melanocytes express COX-2 enzyme and are involved in PGE2 production.
In an attempt to investigate the role of PGE2 in the development of vitiligo, this present study was done. This study included 20 patients with vitiligo and 15 control subjects.
The main function of epidermal melanocytes is to synthesize melanin in response to UVR. Studies suggest that PGE2 plays an important role in melanogenesis. PGE2 stimulates melanocytes dendrite formation, tyrosinase activity, and proliferation in human melanocytes. Researchers got encouraging results when they used topical PGE2 for treatment of vitiligo.
Prostaglandins are synthesized from AA by COX enzymes. The COX enzyme family consists of two isoforms; COX-1 which is constitutively expressed and COX-2 which is inducible. It has been found that UVR-induced COX-2 expression plays a major role in PGE2 production. In the epidermis, both keratinocytes and melanocytes express COX-2 enzyme and are involved in PGE2 production.
In an attempt to investigate the role of PGE2 in the development of vitiligo, this present study was done. This study included 20 patients with vitiligo and 15 control subjects.
Other data
| Title | Evaluation of the Role of Prostaglandin E2in the Pathogenesis of Vitiligo | Other Titles | تقييمدورالبروستاجلاندين اى2 فىتطورمرضالبهاق | Authors | Asmaa Galal Elbadawy Taher Mohamed | Issue Date | 2015 |
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