RELATIONSHIP BETWEEN METABOLIC SYNDROME AND ACUTE CORONARY SYNDROME IN CRITICAL CARE UNIT

Abstract

M S consists of a group of metabolic risk factors which increase the incidence of CVD and type 2DM. Obesity and physical inactivity are not only causes of MS but some people are more susceptible to have the syndrome than others because of disturbance in genetic factors, energy balance and ethnicity. Although, genetic susceptibility has important role, but the incidence of MS is unusual in absence of obesity and physical in activity. So life style modification, loss of weight and increase physical activity considered the first line in treatment of MS. IR is the hallmark of MS and plays an essential role in its incidence. Not need to be remembered that stop smoking is very important in those patient. MS patient need to lose from 7-10 percent of their weight in the first 6-12 months in addition to at least 30 minutes daily of moderate physical activity at the same time. Balanced diet is very important in those patients which contain little amount of fats (saturated and unsaturated) and simple sugar but more amount of fruits, vegetables and whole grains. If life style modification, weight reduction and increase physical activity failed to stop MS incidence, patients should follow the current guidelines for MS treatment. Risk factors of CVD include, smoking, HTN, DM and dyslipidemia are mostly involved in MS and should be controlled according to the last guidelines. The role of MS in atherosclerosis (ox-LDL, HDL) is well proven moreover, there is reciprocal relationship between IR and ED (decreased NO and increased endothelin-1) the matter that help us to understand the relationship between metabolic syndrome and acute coronary syndrome.