ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS AND SELECTED CHEMICAL MEDIATORS AS FOR THE ANTI-ULCER ACTIVITY OF NICORANDIL IN RATS
Hisham Ahmed Fawzy Ismail;
Abstract
The present investigation was an attempt to evaluate the anti-ulcer activity of nicorandil (in two dose levels) in water immersion-restraint stress (WIRS)- and indomethacin-induced ulcer models. In addition, the role of ATP-sensitive potassium (KATP) channels and the possible involvement of some chemical mediators, namely, histamine, lipid peroxides, prostaglandin E2 (PGE2) and nitric oxide (NO) as targets for the ulcer-protective action of nicorandil, were
investigated.
investigated.
Other data
| Title | ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS AND SELECTED CHEMICAL MEDIATORS AS FOR THE ANTI-ULCER ACTIVITY OF NICORANDIL IN RATS | Other Titles | دورقنوات البوتاسيوم الحساسة للاية تى بى وموصلات كيمائية مختارة كمستهدفات لتاثير النيكورانديل المضاد للقرح فى الجرذان | Authors | Hisham Ahmed Fawzy Ismail | Issue Date | 2005 |
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