Synthesis of some new azoles, azines and their fused derivatives from laboratory available starting compounds
Nehal Ahmed Sobhy EI-Moshneb;
Abstract
This original work of this thesis includes THREE research projects:
The first project: deals with the reaction of the arylidene malononitriles with
1,3-cyclohexanedione, dimedone and pyrazolone derivatives to afford the
chromene and the pyranopyrazole derivatives. The molluscicidal activity of the synthesized compounds towards Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni, was investigated.
The second project: deals with the self dimerization of 2-(1-aryl-ethylidene)
malononitriles in ethanol catalyzed by sodium ethoxide to afford 2-(3-cyano-6- methyl-4,6-diaryl-5,6-dihydro-1H-pyridine-2-ylidiene)malononitriles.
The structure of these dimers were elucidated by X-ray crystallography and a plausible mechanism has been postulated to account for their formation. One of
the obtained dimers was allowed to react with different reagents to afford hydrazo and naphthyridine derivatives which were required for their biological
activities.
The third project: investigates the reactions of bis-enaminone which was
allowed to react with twofold excess of different reagents to afford acyclic derivatives which could be cyclized to give different his-heterocyclic carboxamides.
The first project: deals with the reaction of the arylidene malononitriles with
1,3-cyclohexanedione, dimedone and pyrazolone derivatives to afford the
chromene and the pyranopyrazole derivatives. The molluscicidal activity of the synthesized compounds towards Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni, was investigated.
The second project: deals with the self dimerization of 2-(1-aryl-ethylidene)
malononitriles in ethanol catalyzed by sodium ethoxide to afford 2-(3-cyano-6- methyl-4,6-diaryl-5,6-dihydro-1H-pyridine-2-ylidiene)malononitriles.
The structure of these dimers were elucidated by X-ray crystallography and a plausible mechanism has been postulated to account for their formation. One of
the obtained dimers was allowed to react with different reagents to afford hydrazo and naphthyridine derivatives which were required for their biological
activities.
The third project: investigates the reactions of bis-enaminone which was
allowed to react with twofold excess of different reagents to afford acyclic derivatives which could be cyclized to give different his-heterocyclic carboxamides.
Other data
| Title | Synthesis of some new azoles, azines and their fused derivatives from laboratory available starting compounds | Other Titles | تشييد بعض الآزولات والآزينات ومشتقاتهم الملتحمة الجديدة من بادئات متوافرة معمليا | Authors | Nehal Ahmed Sobhy EI-Moshneb | Keywords | 4-Pyridyl-chromenes/ 4-Pyridyl-pyrano[2,3-c]pyrazoles/ 4-Pipronyl-chromenes/ 4-Pipr -onyl-pyrano[2,3-c]pyrazoles/ Pyrano[2,3-c]pyrazoles/ Molluscicidal activity/ Pyridine/ Cinnamonitriles I Carboxamides/ Acrylamides/ Bis-enaminones/ Pyrazolo[3,4 h)[1,6] naphthyridines/ Pyrimido[4,5-h}[1,6}naphthyridines/ Pyrido[3,2-c}pyridazine. | Issue Date | 2010 |
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