DEMONSTRATION OF CARCINOEMBRYONIC ANTIGEJ i AND PROLIFERATING CELL NUCLEAR ANTIGEN IN SOME PROLIFERATIVE DERMATOSIS
GHADA GALAL YOUNES ISMAEL;
Abstract
Carcinoembryonic antigen (CEA) was recognized as being important not only as a tumour marker, but also as a cell adhesion molecule in the metastasis of malignant tumour cells, and in the development of inflammatory disorders in some organs.
CEA and related antigens were expressed by epidermal keratinocytes and by some infiltrating cells in inflammed skin. The expression was observed in the upper layers of the epidermis. So, there was an additional role for CEA-related molecules which is that they may be associated with the state of differentiation of epidermal keratinocytes. It was found that proliferating cell nuclear antigen (PCNA) is a 36 KDa acidic non-histone nuclear protein which functions as an auxiliary protein for DNA polymerase a. PCNA is tightly associated to the sites of DNA replication and probably must have a role in DNA synthesis. PCNA synthesis is increased in late G1 and inS-phase of the cell cycle.
The present study was undertaken to demonstrate the role of CEA and
PCNA expression in squamous cell carcinoma and verruca vulgaris.
This study included thirteen patients . with verruca vulgaris and seven patients with squamous cell carcinoma, were selected from the out patients clinics, of Dermatology and venerology Department, Tanta univesity Hospitals . In addition to 10 control subject who were dermatologically free. For all, the following were done:
1) Full history taking.
2) Thorough clinical and dermatological examinations.
3) Routine laboratory investigations.
1- Complete blood picture
n- Renal and hepatic function tests.
m- Fasting and postprandial blood sugar. iv- Urine and stool analysis.
CEA and related antigens were expressed by epidermal keratinocytes and by some infiltrating cells in inflammed skin. The expression was observed in the upper layers of the epidermis. So, there was an additional role for CEA-related molecules which is that they may be associated with the state of differentiation of epidermal keratinocytes. It was found that proliferating cell nuclear antigen (PCNA) is a 36 KDa acidic non-histone nuclear protein which functions as an auxiliary protein for DNA polymerase a. PCNA is tightly associated to the sites of DNA replication and probably must have a role in DNA synthesis. PCNA synthesis is increased in late G1 and inS-phase of the cell cycle.
The present study was undertaken to demonstrate the role of CEA and
PCNA expression in squamous cell carcinoma and verruca vulgaris.
This study included thirteen patients . with verruca vulgaris and seven patients with squamous cell carcinoma, were selected from the out patients clinics, of Dermatology and venerology Department, Tanta univesity Hospitals . In addition to 10 control subject who were dermatologically free. For all, the following were done:
1) Full history taking.
2) Thorough clinical and dermatological examinations.
3) Routine laboratory investigations.
1- Complete blood picture
n- Renal and hepatic function tests.
m- Fasting and postprandial blood sugar. iv- Urine and stool analysis.
Other data
| Title | DEMONSTRATION OF CARCINOEMBRYONIC ANTIGEJ i AND PROLIFERATING CELL NUCLEAR ANTIGEN IN SOME PROLIFERATIVE DERMATOSIS | Other Titles | إيضاح مولدات المضاد الجنينية السرطانية والمولد المضاد النووى للخلية المتكاثرة فى بعض أمراض الجلد المتكاثر | Authors | GHADA GALAL YOUNES ISMAEL | Issue Date | 2002 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.