Activated Protein C Resistance in patients with Systemic Lupus Erythematosus
Manal Mahmoud Helal;
Abstract
Activated protein C (APC) is a naturally occurring anticoagulant that interacts with factor V and VIII to inhibit the coagulation cascade.
The aim of the present study is to investigate the prevalence of APC resistance in Egyptian patients with systemic lupus erythematosus (SLE). APC ratio was performed on 40 SLE patients who visited Kasr EL Aini Hospital, Faculty of Medicine, Cairo University, and 20 healthy persons as controls. Lupus anticoagulant (LAC) and anticardiolipin antibodies (aCL) were determined in all patients. Six patients and one control subject had APC ratio <2.0 which corresponded to the presence of APC resistance. No significant difference in the risk of APC resistance has been found between SLE cases and control subjects. Out of the six SLE cases with APC resistance; four had a history ofthrombsis and two had no thrombosis.
In conclusion: APC resistance 1s an uncommon risk factor for thrombosis in SLE patients.
The aim of the present study is to investigate the prevalence of APC resistance in Egyptian patients with systemic lupus erythematosus (SLE). APC ratio was performed on 40 SLE patients who visited Kasr EL Aini Hospital, Faculty of Medicine, Cairo University, and 20 healthy persons as controls. Lupus anticoagulant (LAC) and anticardiolipin antibodies (aCL) were determined in all patients. Six patients and one control subject had APC ratio <2.0 which corresponded to the presence of APC resistance. No significant difference in the risk of APC resistance has been found between SLE cases and control subjects. Out of the six SLE cases with APC resistance; four had a history ofthrombsis and two had no thrombosis.
In conclusion: APC resistance 1s an uncommon risk factor for thrombosis in SLE patients.
Other data
| Title | Activated Protein C Resistance in patients with Systemic Lupus Erythematosus | Other Titles | مقاومة بروتين ( ج ) النشط فى مرضى الذئبة الحمراء | Authors | Manal Mahmoud Helal | Keywords | .Activated protein C resistance - Systemic lupus erythematosus (SLE) Thrombosis | Issue Date | 2001 |
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