Galectin-3 Level in Liver Injured Rats Treated with Nigella sativa and Honey Mixture

Mahmoud Abdel Halim Abdel Monem Sayed


Abstract


The current study was carried out to investigate the potential inhibitory effect of Nigella sativa (black seed) and honey, as mixture and separately, on galectin-3 level in thioacetamide induced liver fibrosis in rats. Both of Nigella sativa and honey are well known for their medicinal properties especially their hepatoprotective and anti-fibrotic properties against various hepatotoxins. Galectin-3 (Gal-3) is β-galactoside binding lectin that appeared recently to have primary role in TGF-β1 induced fibrogenesis. Galectin-3 expression was found to increase during liver induced injury and propagation of fibrosis, as well as galectin-3 gene knockout attenuates fibrogenesis progression in experimental liver fibrosis models. Because of their hepatoprotective and anti-fibrotic properties, Nigella sativa and honey are probable candidates to have inhibitory


Other data

Other Titles مستوى جالكتين-3 فى الجرذان المصابة فى الكبد والمعاملة بخليط حبة البركة والعسل
Issue Date 2017
URI http://research.asu.edu.eg/handle/12345678/12650


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