The Relation between Echocardiographic Features and Androgen Profile in Newly Diagnosed Patients with Congenital Adrenal Hyperplasia

Abstract

Congenital adrenal hyperplasia (CAH) is one of the most frequent congenital endocrine disorders; it comprises autosomal recessive disorders of cortisol biosynthesis in the adrenal gland caused by various enzyme deficiencies. The consequent compensatory rise of ACTH production causes hyperplastic growth of the adrenal glands. This study aimed to assess echo-cardio graphic functions in infants with congenital adrenal hyperplasia at base line before starting glucocorticoid therapy. The present study has been conducted on thirteen patients with congenital adrenal hyperplasia following up at the Paediatric Endocrinology Clinic of Ain-Shams University Hospitals. Patients were subjected to a detailed history taking and examination, anthropometric evaluation, , hormonal assay for androgen profile, Karyotyping, molecular study and echo-cardio graphic examination.