Stress Cytokines and Cortisol Serum Levels in Dementia
Michael Nazmy Agban;
Abstract
In recent years, many studies have indicated an involvement of inflammatory mechanisms in Alzheimer's dementia (AD). Several cytokines, C reactive protein (CRP), and hypothalamic-pituitary-adrenal axis activity manifested by elevated cortisol level have been associated with AD
.
neuropathology. Therefore, we investigated fifty patients with the clinical .
diagnosis of AD selected using mini-mental state examination (MMSE)as screening test. Twenty-five aged healthy subjects were selected as control. Screened positive subjects were submitted to:
-Personal interview using the Instrumental Activities of Daily
Living Scale,
-Memory assessment by Wechsler Adult Memory Scale,
-And Hachinski Ischaemic score and CT brain to differentiate multi-infarct dementia from Alzheimer's dementia.
-Geriatric Depression Scale excluded depressive pseudodementia. The clinical diagnosis of AD was made according to recommendations
of National institution of Neurological and Communicative disorders Alzheimer's disease and related disorder association (NINCDS-ADARDA) and Diagnostic and Statistical manual-lY (DSM IV) criteria.
Serum sample was taken from patient and control for determination of
!L-IB; IL-6, cortisol and CRP levels.
There was statistically significant increase 111 serum levels of IL-l B, IL-6, cortisol and CRP in AD compared to control suggesting that inflammatory mechanisms and hypercortisolemia may play a role in pathogenesis of the disease.
.
neuropathology. Therefore, we investigated fifty patients with the clinical .
diagnosis of AD selected using mini-mental state examination (MMSE)as screening test. Twenty-five aged healthy subjects were selected as control. Screened positive subjects were submitted to:
-Personal interview using the Instrumental Activities of Daily
Living Scale,
-Memory assessment by Wechsler Adult Memory Scale,
-And Hachinski Ischaemic score and CT brain to differentiate multi-infarct dementia from Alzheimer's dementia.
-Geriatric Depression Scale excluded depressive pseudodementia. The clinical diagnosis of AD was made according to recommendations
of National institution of Neurological and Communicative disorders Alzheimer's disease and related disorder association (NINCDS-ADARDA) and Diagnostic and Statistical manual-lY (DSM IV) criteria.
Serum sample was taken from patient and control for determination of
!L-IB; IL-6, cortisol and CRP levels.
There was statistically significant increase 111 serum levels of IL-l B, IL-6, cortisol and CRP in AD compared to control suggesting that inflammatory mechanisms and hypercortisolemia may play a role in pathogenesis of the disease.
Other data
| Title | Stress Cytokines and Cortisol Serum Levels in Dementia | Other Titles | مستوى السيتوكينات الناشئةعن الضغوط والكورتيزول فى مصل مرضى العته | Authors | Michael Nazmy Agban | Issue Date | 2002 |
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