Definitive radiotherapy in laryngeal cancer patients - retrospective study from single institution

Abstract

This is a retrospective study of laryngeal cancer patients who were treated by radical RT with or without concurrent chemotherapy at the National Cancer Institute, Cairo University, during the period from 2007 to 2013. These represented 141 patients. The aim of this work was to Study the clinico-epidemiological characteristics of the patients, analyze the prognostic factors of the disease and to analyze the results of different treatment modalities and their effect on loco-regional control (LRC) and overall survival (OS). The mean age was 60 years. Most of the patients were of performance status I (73.8%). Squamous cell carcinoma was the most common pathological type (93%). Patients with laryngeal cancer commonly presented with a hoarseness of voice (92.9%), glottic carcinoma represent 57.4% while supraglottic carcinoma represent 38.3%. T1 represents 58.6% of early stage laryngeal cancer patients, while T3 represents 56.4% of advanced stage laryngeal cancer. Patients presented with node negative disease represent 71.6%, while 28.4% of patients had node positive disease. The most frequently used treatment modality in this study was radical RT representing 61%, followed by combined chemoradiotherapy representing 39%. Forty seven patients (33.3%) received CCRT while 35.2% of patients with advanced stage received IC. Out of 141 patients, 116 patients completed the RT course (82.2%). The most common cause of overall RT treatment time prolongation was machine breakdown representing 20.5%.