A COMPARISON OF ORAL, RECTAL AND INTRANASAL MIDAZOLAM ADMINISTRATION FOR PEDIATRIC PREANESTHETIC SEDATION

Abstract

While Previous Studies have demonestrated that the efficacy an'd safety of Preanesthetic sedation in children with orally , r ctally and intranasally administered midazolam, To our Knowledge no direct comparison of the three routes of ' I dministration has been performed to clarify which route is ] . preferable m particular clinical situation. In our study , we

I attempted to evaluate the efficacy of three IJ.lethods of '

administration of midazolam as a preoperative medicant m

children. Also, to clarify which route of administration IS

•' preferable and more convenient in this group of age i

l . This work has been carried out in the Anesthesiology I

department of Assiut University Hospital. This study included

eighty children aged between 2-10 yr. The children were assigned

I o one of four groups [ n = 20 per group J : " Control group" '

received distilled water orlly , "oral group" was given 0.5 mg I kg of midazolam orally, " rectal group " was given 0.5 mg I kg diluted with saline rectally and "nasal group" was given 0.2 mg I kg nasally.