SERUM LEPTIN AND INSULIN HORMONE IN HYPO-AND HYPERTHYROIDISM

Abstract

Leptin, a newly defined protem synthesized and secreted from fat cells in both animals and humans, has gained wide attention. Many studies have been conducted on its roles in the regulation ofbody fat storage, energy expenditure, and body weight changes.

Leptin is thought to act as an afferent satiety signal in a feedback loop that putatively affects the appetite and satiety centres of the brain. The ultimate effect of this loop is to regulate body fat mass.

Acute and chronic administration of insulin in vtvo and in vitro increases adipose tissue ob mRNA in rodents. In humans, chronically insulin appears to play an important role in ob mRNA expression and leptin secretion. It is suggested that glucose transport and metabolism are important factors in the regulation of leptin expression and secretion.