EBOLA VIRAL DISEASE
Rawda Abdallah Mohammed Ebaid;
Abstract
Ebola hemorrhagic fever (EHF) is a fatal disease caused by Ebola virus. Last outbreak started in February 2014 in Guinea (Zaire Ebolavirus species). Clinical EHF is characterized by abrupt onset of fever, fatigue, headache, myalgia, and gastrointestinal distress 3–13 days after exposure to virus. Many patients develop hemorrhagic manifestations, which has led to the term “hemorrhagic fever.”
A high Ebola viral load at time of admission is associated with more severe illness and mortality. Death, if it occurs, follows typically 6 to 16 days from first symptoms and is often due to sever hypotension, multiple organ dysfunction and septic shock. Bleeding often indicates a worse outcome, and massive blood loss may result in death, people are often in coma near the end of life.
Measured levels of markers of immune function, endothelial activation, and coagulation in available patient serum samples, are very important to determine whether alterations in levels of these biomarkers were associated with hemorrhagic manifestations and viraemia. Diagnosis by standard real-time RT-PCR in an outbreak were eventually deployed in the 2014-2015 epidemic, their integration into sustainable regional laboratory capacities for ongoing surveillance and response to future outbreaks will be a great challenge.
A high Ebola viral load at time of admission is associated with more severe illness and mortality. Death, if it occurs, follows typically 6 to 16 days from first symptoms and is often due to sever hypotension, multiple organ dysfunction and septic shock. Bleeding often indicates a worse outcome, and massive blood loss may result in death, people are often in coma near the end of life.
Measured levels of markers of immune function, endothelial activation, and coagulation in available patient serum samples, are very important to determine whether alterations in levels of these biomarkers were associated with hemorrhagic manifestations and viraemia. Diagnosis by standard real-time RT-PCR in an outbreak were eventually deployed in the 2014-2015 epidemic, their integration into sustainable regional laboratory capacities for ongoing surveillance and response to future outbreaks will be a great challenge.
Other data
| Title | EBOLA VIRAL DISEASE | Other Titles | مرض الإيبولا الفيروسي | Authors | Rawda Abdallah Mohammed Ebaid | Issue Date | 2017 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.