Fresh Amniotic Membrane Transplantation in Superficial Wound Dehiscence of Anterior Abdominal Wall

Abstract

SUMMARY ormal wound healing is a complex process involving interaction of multiple cell types, inflammatory cells, platelets and stem cells. Disruption of wound healing may be due to systemic disease such as diabetes and atherosclerosis or due to number of cellular and molecular defects including growth factor signaling, imbalances of matrix metalloprotineases and impaired recruitment of progenitor cells. Different Theories are conducted to explain the local factors contribute to non- healing wounds as decreased collagen production, impaired fibroblasts proliferation, Decrease cells migration power, fibroblasts had become senescent, Cells proliferation may be normal but tissue lacks a structure over which cells migrate, etc... . Ideal dressing criteria may involve dressings which remove excess exudates from the wound and allow granulation tissue growth and keep it warm. The ideal dressing criteria also include dressings which protects from infection and safe not containing toxic materials and don’t traumatize the wound when removed. Dressings were categorized as advanced (those with prophylactic and/or therapeutic properties including amorphous material, silicone, hydrocolloid, foam, antimicrobials o