Pharmacological study on the potential effects of Filgrastim in rotenone-induced model of Parkinson’s disease in rats

Abstract

Parkinson’s disease (PD), the most common neurodegenerative movement disorder, remains a major disabling age-related condition, affecting mainly elderly people. Massive progress has been achieved toward the understanding of the pathology of the disease, wherein it is generally agreed that selective degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc) and subsequent depletion of striatal dopamine (DA), as well as accumulation of α-synuclein-containing intraneuronal inclusions (Lewy bodies [LB]) constitute the two major neuropathological hallmarks of PD. However, the molecular pathogenesis underlying the onset and progression of degeneration in PD is not entirely unveiled despite the tremendous efforts that have been made.