Adjuvant Drugs In Spinal And Epidural Analgesia

Abstract

Central Neuraxial Block occupies an important part in anaesthesia and pain management. Local anaesthetic agents block the generation and propagation of action potential in all excitable tissues primarily by impairing the function on sodium channels in the axonal membrane. A wide variety of adjuvant agents are used along with local anaesthetic mixtures to enhance and prolong the reaction, reduce unwanted motor weakness and autonomic dysfunction and reduce central nervous system and cardiovascular toxicity. Neuraxial drug administration describes the technique of delivering analgesics and other drugs in close proximity to the spinal cord i.e. intrathecally into cerebrospinal fluid (CSF) or epidurally into the epidural space .