COMPARATIVE STUDY BETWEEN THE PRE-EMPTIVE ANALGESIC EFFECT OF EITHER ROPIVACAINE LOCAL INFILTRATION OR INTRAVENOUS KETOROLAC VERSUS THEIR POST-OPERATIVE ADMINISTRATION IN LOWER ABDOMINAL SURGERY

Abstract

The ann of this work was to compare the pre-emptive analgesic effect of either locally infiltrated ropivacaine hydrochloride or intravenous ketorolac versus their post-operative administration in lower abdominal surgery under general anaesthesia. Ketorolac tromethamine is a NSAJD, proved to be very eJTective in

treating post-operative pain, and may be given orally, intramuscularly or intravenously. Post-operative pam, although frequently encountered. is olkn under-treated. A variety of drugs may be used. These include local anaesthetics, NSAJDS, opioids, and ketamine. These may be given before, during or after surgery, by intramuscular, intravenous, local infltration, epidural, sub-arachnoid or intra-articular routes.

Preemptive analgesia is a method that seeks to prevent or diminish pain before its occurrence. Preemptive analgesia describes a situation where the administration of a phannacological agent before the onset of a painful stimulus causes decrease in the intensity of pain and subsequently decreases the total amount of analgesia required.

Ropivacaine hydrochloride is a new local analgesic. It has consistently demonstrated an improved safety profile, a wider clinical utility in high and low dose ranges, and proven dose dependent specificity for surgical anaesthesia and acute pain management.