The Role Of Sirtuin 1 in Diabetic Nephropathy
Haidi Shebl Ahmed EL-Ghandour;
Abstract
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus; it initially manifests with microalbuminurin and progresses towards end-stage renal failure. Sustained diabetes-related metabolic and haemodynamic perturbations can induce subclinical low-grade renal inflammation and drive kidney from repair response to damage process, eventually to renal fibrosis (Shirong et al., 2016).
The aim of the present study is to investigate the relationship between serum situin 1 and advanced glycation end products (AGEs) in Egyptian patients with type II diabetes and patients with diabetic nephropathy.
Diabetic patients and healthy control individuals (100 males and females) were fully studied by means of clinical and laboratory examinations before being selected for this study. The groups divided as the following:
Group (I) which contains 20 healthy individuals, group (II) contians 30 normoalbuminuric patients, group(III) includes 50 patients with diabetic nephropathy, group (IIIa) contains 30 patients with microalbuminuria and group (IIIb) contains 20 macro- albuminuric patients.
The following parameters are estimated: fasting plasma glucose, insulin, HOMA-IR, totalcholesterol, triglycerides, HDL-C, LDL-C, urea, creatinine, blood urea nitrogen, AGEs, microalbumin and serum sirtuin-1.
The results can be summarized as following:
1. FPG showed a highly significant increase
The aim of the present study is to investigate the relationship between serum situin 1 and advanced glycation end products (AGEs) in Egyptian patients with type II diabetes and patients with diabetic nephropathy.
Diabetic patients and healthy control individuals (100 males and females) were fully studied by means of clinical and laboratory examinations before being selected for this study. The groups divided as the following:
Group (I) which contains 20 healthy individuals, group (II) contians 30 normoalbuminuric patients, group(III) includes 50 patients with diabetic nephropathy, group (IIIa) contains 30 patients with microalbuminuria and group (IIIb) contains 20 macro- albuminuric patients.
The following parameters are estimated: fasting plasma glucose, insulin, HOMA-IR, totalcholesterol, triglycerides, HDL-C, LDL-C, urea, creatinine, blood urea nitrogen, AGEs, microalbumin and serum sirtuin-1.
The results can be summarized as following:
1. FPG showed a highly significant increase
Other data
| Title | The Role Of Sirtuin 1 in Diabetic Nephropathy | Authors | Haidi Shebl Ahmed EL-Ghandour | Issue Date | 2018 |
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