Evaluation of Some Compounds as Radioprotectors Against Radiation Induced Genetic Damage in Mice

Abstract

The objective of the present study was to evaluate the efficacy of resveratrol , a natural compound from plant origin and dried roots of Rumex sp. against the genotoxicity induced by - irradiation in mice. Two doses of resveratrol were selected, 50, 100 mg/kg. bw and repeated doses of 50 mg/kg. bw for 5 consecutive days. The two doses of Rumex were 25, 50 mg/kg. bw and repeated doses of 25 mg/kg. bw for 5 consecutive days. Animals were exposed to a dose of 4 GY of ray 30 minutes post treatment, and bone marrow was then harvested one day post irradiation. The present result showed that the mean percentage of chromosomal aberrations induced by - irradiation reduced in animals treated with single low or high dose of resveratrol, this reduction was greatly reduced when animals received 5 consecutive repeated doses prior to irradiation. Results also demonstrated that single dose of Rumex sp. (25 and 50 mg) reduced the mean percentage of chromosomal aberrations induced by - irradiation and the repeated doses showed more reduction which was highly significant. In conclusion, the present study showed that both resveratrol and Rumex sp. can be used as radioprotective agents to minimize the genotoxic effect of - irradiation.