CONSTRUCTION AND PERFORMANCE CHARACTERISTICS OF NEW ION-SELECTIVE ELECTRODES FOR SOME PHARMACEUTICAL COMPOUNDS

Abstract

The present work compnses the determination of the pharmaceutical compounds Amprolium and Metoclopramide in both the pure form and in the fommlated pham1aceutical preparations using the standard additions, potentiometric titration methods and flow injection analysis (FIA) conditions. Construction and performance of ion-selective electrodes of C-paste types based on ion-associates of amprolium with phosphotungstate and metoclopramide with tetraphenylbonite ions have been investigated .The effect of pH of the test solutions, temperature and time on the electrodes performance are studied. The electrodes are highly selective for the dmgs with respect to several inorganic cations, sugars and some amino acids. Key words: Phannaceutical compounds, Amprolium hydrochloride, Metoclopramide hydrochloride, FIA, Potentiometry, ion-selective electrodes.