Comparatmve Toxmco!ogm lltudy Between Some Mem ers-01 .-'1< . . ' -- :•; fluoroqu no one AntimicrobialAgents In Albino Rats

Abstract

What has forcing the scientists and researchers to develop and invent an antimicrobial agents and continue to do so? Without doubt the presence of infec­ tious organisms and the continuous appearance of new generation of the organ­ isms that are more resistant to the old antimicrobial agents. Hence the impor­ ta,lce of finding a new, powerful, and safe antibiotics to overcome the serious . adverse effects of the invasive organisms to both humanbeing and animals. The role of antibiotics and antimicrobials in poisoning as well as drug­

induced adverse effects becomes increasingly important because of their exten­ sive use all over the world and no one in the whole world did not administered any of this class. One of the recently introduced family is quinolones or fluoro­ quinolones (QLs or FQs) which are the newest as well as the most commonly used drugs as antiifective agents worldwide in nearly all countries because of their high effectiveness in eradicating infectious diseases especially respiratory and urinary tract. In addition, FQs have considerable and practical pharmacoki­ netic features, including excellent oral absorption, excellent tissue distribution, significant interstitial fluid levels, substantial phagocytic cellular levels, good lung and urinary concentrations, and long half-lives. Year after year there are thousands of structurally related agents that have been introduced into the infec­ I tious disease market, some of them showed excellent results and others were

withdrawn from the market because of their severe side-effects and toxicities.