Clinical Significance of Expression of Stimulatory and Inhibitory Pathway by Studying the Platelet Derived Growth Factor and Transforming Growth Factor "B" in Patients with Carcinoma of the Bladder
Hani Hazem Mamoun Nour;
Abstract
Carcinoma of the bladder is responsible for a large percentage of monalit-y due to cancer worldwide. In Egypt, it is the co111monest malignancy affecting men. The promoter and inhibitory factors are so far not identified.
Cell growth, motility, differentiation and apoptosis are regulated in part by signals received by cells from environment.
Cancer cells are characterized by their lack of growth control. Accumulating evidence support the notion that this involves constitutive activation of signaling pathways that, in the normal cells are controlled by growth stimulatory factors, or loss of functional activity of components in
growth inhibitory pathways.
Jn our study we are going to focus on two important growth regulatory factors, platelet-derived growth factor (PDGF), and transforming growth factor-B (TGF-B).
PDGF is a family of dimeric isoforms of four structurally similar gene products, these isoforms act mainly on connective tissue.
PDGF has functional roles during embryonal development and m promoting wound healing, and regulate interstitial fluid pressure.
Cell growth, motility, differentiation and apoptosis are regulated in part by signals received by cells from environment.
Cancer cells are characterized by their lack of growth control. Accumulating evidence support the notion that this involves constitutive activation of signaling pathways that, in the normal cells are controlled by growth stimulatory factors, or loss of functional activity of components in
growth inhibitory pathways.
Jn our study we are going to focus on two important growth regulatory factors, platelet-derived growth factor (PDGF), and transforming growth factor-B (TGF-B).
PDGF is a family of dimeric isoforms of four structurally similar gene products, these isoforms act mainly on connective tissue.
PDGF has functional roles during embryonal development and m promoting wound healing, and regulate interstitial fluid pressure.
Other data
| Title | Clinical Significance of Expression of Stimulatory and Inhibitory Pathway by Studying the Platelet Derived Growth Factor and Transforming Growth Factor "B" in Patients with Carcinoma of the Bladder | Other Titles | التحليل الإكلينيكي للدلالات المنبهه والمثبطه للأورام بواسطه دراسة العامل المنمى للصفائح الدموية وعامل النمو المتغير " “B فى مرضى سرطان المثانة | Authors | Hani Hazem Mamoun Nour | Issue Date | 2003 |
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