Study of Interferon-gamma and Vascular Endothelial Growth Factor as Factors Affecting Angiogenesis in Patients with Breast Cancer
Pansee Abdelrahim Mohamed Abdelrahim;
Abstract
Breast cancer is the most common malignancy affecting females. One in nine women will develop the disease during their lifetime. Multiple studies have shown that angiogenesis (the growth of new blood vessels) plays an important role in the growth, progression, and metastasis of solid tumors.
It depends on the production of angiogenic factors by host and or tumor cells. VEGF is believed to be one of the most important of the angiogenic factors. ill some studies VEGF is over-expressed in human breast cancer with subsequent promotion of angiogenesis.
Angiogenesis is indirectly inhibited in vivo by IL-12, which induces secondary cytokines mainly INF-y and other downstream mediators. IFN-y is released by T helper lymphocytes and to a lesser extent by CD8+ T cells and natural killer cells. It has the unique ability to exert various cell mediated immunoregulatory functions. These functions are important in combat against tumor cells.
The aim of this study was to investigate the role of VEGF as an angiogenic factor and IFN-y as an antiangiogenic factor and a mediator of cellular immunity in human breast cancer.
It depends on the production of angiogenic factors by host and or tumor cells. VEGF is believed to be one of the most important of the angiogenic factors. ill some studies VEGF is over-expressed in human breast cancer with subsequent promotion of angiogenesis.
Angiogenesis is indirectly inhibited in vivo by IL-12, which induces secondary cytokines mainly INF-y and other downstream mediators. IFN-y is released by T helper lymphocytes and to a lesser extent by CD8+ T cells and natural killer cells. It has the unique ability to exert various cell mediated immunoregulatory functions. These functions are important in combat against tumor cells.
The aim of this study was to investigate the role of VEGF as an angiogenic factor and IFN-y as an antiangiogenic factor and a mediator of cellular immunity in human breast cancer.
Other data
| Title | Study of Interferon-gamma and Vascular Endothelial Growth Factor as Factors Affecting Angiogenesis in Patients with Breast Cancer | Other Titles | دراسة الانترفيرون – جاما وعامل النمو للخلايا المبطنة للأوعية الدموية كعوامل مؤثرة لتكوين الأوعية الدموية فى مرضى سرطان الثدى | Authors | Pansee Abdelrahim Mohamed Abdelrahim | Issue Date | 2002 |
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