Long QT Syndrome And Anaesthesia

Wael Abdel Hameed El siory


Abstract


Long QT s,•ndrome is a disorder of cardiac Ion channels. Its impo11ance lies in the potential for development of fatal arrhythmias on anaesthesizing undiagnosed patients. Pathophysiology of Long QT syndrome explains the molecular & cellular basis for the disorder and helps understanding the effects of anaesthetic drugs in order to improve anaesthetic management of the disease. Patients with Long QT syndrome are usually diganosed following a cardiac event such as syncope or sudden death .Diagnosis of the condition depends on Standard ECG recordings and analysis of QT corrected for heart rate duration . There is no defenitive treatment for long QT syndrome .However, 13-Biockers can effectively reduce the incidence of cardiac events and reduce mortality rate and so far are the first line of treatment. The effect of anaesthetic drugs on patients with long QT syndrome is defficult to study .However, isoflurane is the safest among inhalational anaesthetics ,while propofol is the preferred intravenous anaesthetic as it decreases the QT corrected for heart rate , cisatracurium is the.preferred muscle relaxant with little effect on the heart and vascular system and great ability to omit reversal .


Other data

Other Titles متلازمة كيو - تى الطويلة والتخدير
Issue Date 2005
URI http://research.asu.edu.eg/handle/12345678/15753


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