Plasma Thrombin Activatable Fibrinolysis Inhibitor Level In Pregnant Women With Preeclampsia And Those With Normal Pregnancy
Ahmed Fouad Hasan;
Abstract
This study was held to investigate the plasma levels of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in pregnant women with pre-eclampsia compared to healthy pregnants as a control.
This study comprised a total of 60 pregnant women who delivered in maternity hospital, Ain Shams University during the period March 2012 - October 2013. Informed consent was obtained from all women after fully explaining the procedure involved and the research nature. The study was approved by the Research Ethical Committee of Ain Shams University. The 60 women consisted of 2 groups:
Group I (study group) : Included 30 pregnant women with documented preeclampsia.
Group II (control group): Included 30 women with normal uncomplicated term pregnancy.
All subjects were subjected to a complete history taking, complete clinical examination, and laboratory investigations included Urinary albumin excretion and Plasma TAFI level by ELISA.
Our study showed no significant changes in age, smoking and parity between patients and controls (p=0.793; p=0.222; p=0.813) respectively.
Our study showed statistically significant in weight and pre-existing hypertension between patients and controls (p=<0.001; p=<0.001) respectively. Also showed statistically significant between the two groups as the SBP (p<0.001), DPB (p<0.001), lower limb edema (p<0.001), proteinuria (p<0.001) in the pre-eclamptic group while non in the control group had hypertension nor lower limb edema nor proteinuria.
Our study show that the TAFI level was significantly higher in the pre-eclamptic group compared with the control group (19.2±{0.89} and 10.65±{0.95}, respectively ; p<0.001.).
In the current study showed significant correlation between the TAFI level and weight (correlation coefficient = 0.548; p<0.001) and also between the TAFI level and SBP (correlation coefficient = 0.920; p<0.001).
Our study showed significant correlation between the TAFI level and DBP (correlation coefficient = 0.919; p<0.001) and also positive correlation with proteinuria (correlation coefficient = 0.881; p<0.001).
Our study showed the correlation between TAFI level and various variables in the preeclamptic group as:
• There was positive correlation between TAFI level and DBP (correlation coefficient = 0.439; p=0.015), and also there was positive correlation between TAFI level and proteinuria (correlation coefficient = 0.521; p=0.003).
The area under the roc curve (AUC) was 1.0 (95% CI = 0.9 – 1; p<0.0001) donating excellent diagnostic value of the TAFI level.
Our study showed that the best cutoff point is a TAFI level >12 µg/ml. and this cutoff had a sensitivity of 100% (95% CI = 88.4% – 100.0%) and specificity of 100% (95% CI 88.4% - 100%).
This study comprised a total of 60 pregnant women who delivered in maternity hospital, Ain Shams University during the period March 2012 - October 2013. Informed consent was obtained from all women after fully explaining the procedure involved and the research nature. The study was approved by the Research Ethical Committee of Ain Shams University. The 60 women consisted of 2 groups:
Group I (study group) : Included 30 pregnant women with documented preeclampsia.
Group II (control group): Included 30 women with normal uncomplicated term pregnancy.
All subjects were subjected to a complete history taking, complete clinical examination, and laboratory investigations included Urinary albumin excretion and Plasma TAFI level by ELISA.
Our study showed no significant changes in age, smoking and parity between patients and controls (p=0.793; p=0.222; p=0.813) respectively.
Our study showed statistically significant in weight and pre-existing hypertension between patients and controls (p=<0.001; p=<0.001) respectively. Also showed statistically significant between the two groups as the SBP (p<0.001), DPB (p<0.001), lower limb edema (p<0.001), proteinuria (p<0.001) in the pre-eclamptic group while non in the control group had hypertension nor lower limb edema nor proteinuria.
Our study show that the TAFI level was significantly higher in the pre-eclamptic group compared with the control group (19.2±{0.89} and 10.65±{0.95}, respectively ; p<0.001.).
In the current study showed significant correlation between the TAFI level and weight (correlation coefficient = 0.548; p<0.001) and also between the TAFI level and SBP (correlation coefficient = 0.920; p<0.001).
Our study showed significant correlation between the TAFI level and DBP (correlation coefficient = 0.919; p<0.001) and also positive correlation with proteinuria (correlation coefficient = 0.881; p<0.001).
Our study showed the correlation between TAFI level and various variables in the preeclamptic group as:
• There was positive correlation between TAFI level and DBP (correlation coefficient = 0.439; p=0.015), and also there was positive correlation between TAFI level and proteinuria (correlation coefficient = 0.521; p=0.003).
The area under the roc curve (AUC) was 1.0 (95% CI = 0.9 – 1; p<0.0001) donating excellent diagnostic value of the TAFI level.
Our study showed that the best cutoff point is a TAFI level >12 µg/ml. and this cutoff had a sensitivity of 100% (95% CI = 88.4% – 100.0%) and specificity of 100% (95% CI 88.4% - 100%).
Other data
| Title | Plasma Thrombin Activatable Fibrinolysis Inhibitor Level In Pregnant Women With Preeclampsia And Those With Normal Pregnancy | Other Titles | دراسة نسبة مانع انحلال الفيبرين المنشط بواسطة الثرومبين فى الحوامل اللاتى يعانين من مرض تسمم الحمل مقارنة بالحمل الطبيعى | Authors | Ahmed Fouad Hasan | Issue Date | 2014 |
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