Role of Intralipid in Patients with Unexplained Recurrent Spontaneous Abortion A randomized Controlled Clinical Trial

Abstract

Dys-regulations in the normal maternal immune system probably operates at the maternal-fetal interface and may involve increased activity of both uterine and peripheral natural killer cells, which appear to regulate placental and trophoblast growth, local immunomodulation, and control of trophoblast invasion. These and other aspects of immunologically-mediated infertility are not well defined. This study aimed at studying the effect of Intralipid on the success of early pregnancy (20 weeks) in women with unexplained recurrent spontaneous abortion. It also aimed at studying the effect of adding Intralipid to the standard treatment of unexplained recurrent miscarriage on the peripheral NK cells. The study was held at Ain Shams University Maternity Hospital. It included 160 patients with history of recurrent spontaneous abortion (2 or more abortions less than 20 weeks gestation). All the patients were less than 35 years old to decrease the risk of chromosomal abnormalities.