EFFECTS Of SOME FOOD POLLUTANTS ON PREGNANT RATS AND THEIR FOETUSES
ELHAM MOUSTAFA HUSSIEN MOUSTAFA;
Abstract
Effects of some food pollutants on pregnant rats and their foetuses.
The present work deals to illustrate and assess the possible
I
adverse effect evoked by radiation and/or tartrazine on the pregnant rats 'i
I
and their foetuses and to evaluate their haematological and their
histological impacts changes on liver and kidney.
The pregnant rats were treated with radiation (1/2 Gy) on the 5th day of gestation and two doses oftartrazine (.2.8, 5.6 mg/kg b.wt) from the 5th to 20th day of gestation singly or in combin•ation.
On the 20th day of gestation, the results have revealed marked
0
decrease ofmatemal body weight, increase in e percentage of abortion and decrease in maternal uterine weight. In addition, to wide haematological disorders which are represented by decrease in erythrocytic count, decrease in haemoglobin content and haematocrite percentage. In addition to increase in total leukocytic count, changes in blood differential, and marked histological changes in their livers and kidneys.
The effect of radiatioil and/or tartrazine on the development rat foetuses were characterized by growth retardation, high percentage of foetal mortality with gross malformations. In addition to decrease m R.B.Cs count and haemoglobin content and increase in• total leu ocytic count with marked histological changes in their livers and kidneys.
Furthermore, the use of radiation alone or in combination with the two dos.s of tartrazine were found to cause effects on both pregnant rats
and their resulting foc>tuses. These effects increase with the highest dose of tartrazine than with the lower one and it was more pronounced in combination gro:1ps than in the groups used radiation or rartrazine alone.
The present work deals to illustrate and assess the possible
I
adverse effect evoked by radiation and/or tartrazine on the pregnant rats 'i
I
and their foetuses and to evaluate their haematological and their
histological impacts changes on liver and kidney.
The pregnant rats were treated with radiation (1/2 Gy) on the 5th day of gestation and two doses oftartrazine (.2.8, 5.6 mg/kg b.wt) from the 5th to 20th day of gestation singly or in combin•ation.
On the 20th day of gestation, the results have revealed marked
0
decrease ofmatemal body weight, increase in e percentage of abortion and decrease in maternal uterine weight. In addition, to wide haematological disorders which are represented by decrease in erythrocytic count, decrease in haemoglobin content and haematocrite percentage. In addition to increase in total leukocytic count, changes in blood differential, and marked histological changes in their livers and kidneys.
The effect of radiatioil and/or tartrazine on the development rat foetuses were characterized by growth retardation, high percentage of foetal mortality with gross malformations. In addition to decrease m R.B.Cs count and haemoglobin content and increase in• total leu ocytic count with marked histological changes in their livers and kidneys.
Furthermore, the use of radiation alone or in combination with the two dos.s of tartrazine were found to cause effects on both pregnant rats
and their resulting foc>tuses. These effects increase with the highest dose of tartrazine than with the lower one and it was more pronounced in combination gro:1ps than in the groups used radiation or rartrazine alone.
Other data
| Title | EFFECTS Of SOME FOOD POLLUTANTS ON PREGNANT RATS AND THEIR FOETUSES | Other Titles | تأثير بعض ملوثات الطعام على الجرذان الحوامل وأجنتها | Authors | ELHAM MOUSTAFA HUSSIEN MOUSTAFA | Keywords | .Radiation - tartrazine (food colour) pregnant rats - foetus - embryo- teratogenic effect- malformations- blood liver- kidney | Issue Date | 1997 |
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