CARDilAC AUTONOMIC DYSFUNCTION lN DlABETICS VERSUS NON DlABETICS AND ITS RELATI01NTO SILENT lSCHEAMIC EPlSODES

Abstract

The study included 30 ischemic male patients who fulfilled the above criteria. There were 15 diabetic patients (NIDDM) with a mean duration of diabetes of 9.3 ± 4.2 years and a mean age of 55.1 ± 7.2 years and 15 nondiabetic patients with a mean age 55.5 ± 8.2 years. Both groups were matched for age (p = 0.888). All patients were subjected to: 1- Full history and clinical examination.

2- Electrocardiographic (ECG) examination.

3- Echocardiographic examination.

4- Exercise treadmill testing was performed according to BROUCE protocol.

5- Cardiac autonomic function was evaluated by five simple bedside cardiovascular reflex tests (HR variation during deep breathing, Lying to standing maximum/ minimum 30:15 ratio, Valsalva ratio, Blood pressure response to standing and Blood pressure response to sustained hand grip). 6- 24-hours ambulatory ECG (Holter monitoring) for measurement ofHRV (Time domain which included SDNN, SDANN inde\, SDNN index, rMSSD and pNN%) and detection of ischemic episodes. 7- Coronary angiography.