CORD VASPIN HORMONE IN INTRAUTERINE GROWTH RESTRICTED NEONATES
Marwa Waheed Abd El Aal Tolba;
Abstract
Summary
I
ntrauterine growth restriction is defined as the pathologic inhibition of intrauterine fetal growth and the failure of the fetus to achieve its growth potential. Considered by the American College of Obstetricians and Gynecologists “the most common and complex problem in modern obstetrics"
One of the most common causes of IUGR is preeclampsia. Preeclampsia has remained a significant public health threat in both developed and developing countries contributing to maternal and perinatal morbidity and mortality globally.
Several studies demonstrated that dysregulation of various adipocyte secreted factors—so-called adipocytokines—occurs in GDM and PE and might play an important role in the pathogenesis of both disease states.
One of the newly identifi ed hormones, vaspin is a visceral adipose tissue derived serine protease inhibitor, member of the serpin family.
Vaspin “known as serpin A12” has insulin-sensitizing properties. In humans, serum vaspin concentrations positively correlate with age, BMI and insulin resistance; however, these associations are abrogated in patients with type 2 diabetes.
In this study we measured cord serum vaspin level in intrauterine growth restricted neonates and correlate it to neonatal anthropometric measures.
The currrent study was a case control observational study conducted in the period from August 2014 to January 2015 in Obstetrics and Gynecology hospital, Ain Shams University on the neonates on the first day of life. The studied groups involved 30 control full term appropriate for gesational age neonates and 30 full term IUGR neonates. The IUGR group was further subdivided into 2 equal groups, according to the presence or absence of maternal preeclampsia.
Group I included 30 full term IUGR neonates,46.6% were males and53.3% females. Their birth weight ranged from 1.3-2 kg mean 1.6kg . Their crown heel length ranged from 28-36cm, mean 31.8cm . OFC ranged 22-30 cm, mean 26 cm . 20% were delivered vaginally and 80% were delivered by C.S.
Group IA is the group of IUGR neonates due to maternal preeclampsia. It included 15 full term IUGR neonates, 53.3% were males and 46.6% females. Their birth weight ranged from 1.3-2 kg, mean 1.5kg . Their crown heel length ranged from 28-34cm, mean 30.2 cm . OFC ranged 22-26 cm, mean 23.8cm . 6.6% were delivered vaginally and 93.3% were delivered by C.S.
Group IB is the group of IUGR neonates of non preeclamptic mothers. It included 15 full term IUGR neonates , 40% were males and 60% females. Their birth weight ranged from 1.5-1.9 kg , mean 1.7 kg . Their crown heel length ranged from 29-36cm , mean 33.3cm . OFC ranged 26-30 cm, mean 28.3cm 33.3 % were delivered vaginally and 66.6% were delivered by C.S.
Group II was the control group. It consisted of 30 full term AGA neonates ,56.7% were males and 43.3% females. Their birth weight ranged from 2.8-3.5 kg , mean 3.1kg . their crown heel length ranged from 37-42cm , mean 39.8cm . OFC ranged 30-33, mean 31.1 cm . 93.3% were delivered vaginally and 6.6% were delivered by C.S .
Our result showed non significant difference between patients and control group as regard parity, maternal BWT, maternal HT and BMI. Also there was no significant difference between patients and control group as regard Apgar score indicating well cross matched group
Our results showed highly statistically significant decrease in IUGR group of non preeclamptic mothers as regard OFC, BWT and ponderal index, and significant decrease in S. Glucose in the same group compared to the control group. S. insulin, HOMA-IR and vaspin were comparable between the 2 groups
Our result showed statistically significant decrease in maternal WT and parity in IUGR neonates of preeclamptic mothers group compared to control group.
Our result showed highly statistically significant decrease as regard neonatal anthropometric measurements in IUGR neonates of preeclamptic mothers compared to control group. Insulin and vaspin levels were comparable in both groups.
Our result showed no statistically significant difference between the IUGR neonates of preeclamptic mothers group and those of non preeclamptic mothers group as regard mode of delivery, maternal WT, HT ,GA and Apgar score.
Our result showed highly statistically significant increase in OFC and length in IUGR neonates of non preeclamptic mothers group compared to those of preeclamptic mothers group . Ponderal index was highly significantly decreased in IUGR group of non preeclamptic mothers compared to those of preeclamptic mothers. S.vaspin level was significantly increased in IUGR neonates of preeclamptic mothers compared to those of non preeclamptic mothers
I
ntrauterine growth restriction is defined as the pathologic inhibition of intrauterine fetal growth and the failure of the fetus to achieve its growth potential. Considered by the American College of Obstetricians and Gynecologists “the most common and complex problem in modern obstetrics"
One of the most common causes of IUGR is preeclampsia. Preeclampsia has remained a significant public health threat in both developed and developing countries contributing to maternal and perinatal morbidity and mortality globally.
Several studies demonstrated that dysregulation of various adipocyte secreted factors—so-called adipocytokines—occurs in GDM and PE and might play an important role in the pathogenesis of both disease states.
One of the newly identifi ed hormones, vaspin is a visceral adipose tissue derived serine protease inhibitor, member of the serpin family.
Vaspin “known as serpin A12” has insulin-sensitizing properties. In humans, serum vaspin concentrations positively correlate with age, BMI and insulin resistance; however, these associations are abrogated in patients with type 2 diabetes.
In this study we measured cord serum vaspin level in intrauterine growth restricted neonates and correlate it to neonatal anthropometric measures.
The currrent study was a case control observational study conducted in the period from August 2014 to January 2015 in Obstetrics and Gynecology hospital, Ain Shams University on the neonates on the first day of life. The studied groups involved 30 control full term appropriate for gesational age neonates and 30 full term IUGR neonates. The IUGR group was further subdivided into 2 equal groups, according to the presence or absence of maternal preeclampsia.
Group I included 30 full term IUGR neonates,46.6% were males and53.3% females. Their birth weight ranged from 1.3-2 kg mean 1.6kg . Their crown heel length ranged from 28-36cm, mean 31.8cm . OFC ranged 22-30 cm, mean 26 cm . 20% were delivered vaginally and 80% were delivered by C.S.
Group IA is the group of IUGR neonates due to maternal preeclampsia. It included 15 full term IUGR neonates, 53.3% were males and 46.6% females. Their birth weight ranged from 1.3-2 kg, mean 1.5kg . Their crown heel length ranged from 28-34cm, mean 30.2 cm . OFC ranged 22-26 cm, mean 23.8cm . 6.6% were delivered vaginally and 93.3% were delivered by C.S.
Group IB is the group of IUGR neonates of non preeclamptic mothers. It included 15 full term IUGR neonates , 40% were males and 60% females. Their birth weight ranged from 1.5-1.9 kg , mean 1.7 kg . Their crown heel length ranged from 29-36cm , mean 33.3cm . OFC ranged 26-30 cm, mean 28.3cm 33.3 % were delivered vaginally and 66.6% were delivered by C.S.
Group II was the control group. It consisted of 30 full term AGA neonates ,56.7% were males and 43.3% females. Their birth weight ranged from 2.8-3.5 kg , mean 3.1kg . their crown heel length ranged from 37-42cm , mean 39.8cm . OFC ranged 30-33, mean 31.1 cm . 93.3% were delivered vaginally and 6.6% were delivered by C.S .
Our result showed non significant difference between patients and control group as regard parity, maternal BWT, maternal HT and BMI. Also there was no significant difference between patients and control group as regard Apgar score indicating well cross matched group
Our results showed highly statistically significant decrease in IUGR group of non preeclamptic mothers as regard OFC, BWT and ponderal index, and significant decrease in S. Glucose in the same group compared to the control group. S. insulin, HOMA-IR and vaspin were comparable between the 2 groups
Our result showed statistically significant decrease in maternal WT and parity in IUGR neonates of preeclamptic mothers group compared to control group.
Our result showed highly statistically significant decrease as regard neonatal anthropometric measurements in IUGR neonates of preeclamptic mothers compared to control group. Insulin and vaspin levels were comparable in both groups.
Our result showed no statistically significant difference between the IUGR neonates of preeclamptic mothers group and those of non preeclamptic mothers group as regard mode of delivery, maternal WT, HT ,GA and Apgar score.
Our result showed highly statistically significant increase in OFC and length in IUGR neonates of non preeclamptic mothers group compared to those of preeclamptic mothers group . Ponderal index was highly significantly decreased in IUGR group of non preeclamptic mothers compared to those of preeclamptic mothers. S.vaspin level was significantly increased in IUGR neonates of preeclamptic mothers compared to those of non preeclamptic mothers
Other data
| Title | CORD VASPIN HORMONE IN INTRAUTERINE GROWTH RESTRICTED NEONATES | Other Titles | دراسة نسبة الفاسبين في الحبل السري في حالات حديثى الولادة متقيدى النمو داخل الرحم | Authors | Marwa Waheed Abd El Aal Tolba | Issue Date | 2015 |
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