Serum Levels of IL-10 in Occult HBV-Infected Patients on Regular Haemodialysis

Abstract

Haemodialysis patients are at high risk for viralhepatitis infections due to multiplebloodtransfusion, vascular access procedures andthe potential for exposure to infected patients andcontaminated HD equipments. HBV is a common nosocomial infections that cause higher rates of mortality and morbidity in maintenance HD patients. HBV infection is a major global health problem.Infection can induce a wide spectrum of clinical formsranging from a healthy carrier state to cirrhosis andhepatocellular carcinoma. Occult HBV infection is characterized by the persistence of HBV genomes in the liver tissue and/or the serum of hepatitis B surface antigen (HBsAg)-negative individuals andthere is a high prevalence of occult HBV infection in patients with haemodialysis. Intheimmunesystem,cytokinesplayan importantroleinappropriateimmuneresponseto viralinfections. The Interleukin 10 cytokine is required for regulating immune functions by promoting the widespread suppression of immune responses through its pleiotropic effects. The autocrine/paracrine capabilities of IL-10 by direct binding to leukocytes and function of this cytokine. So this study was conducted on 80 patients with end stage renal disease undergoing maintenance haemodialysis at Damnhour Medical National Institute-Internal Medicine Department. Aiming to evaluate the role of IL 10 in Occult HBV patients with ESRD on regular haemodialysis. All patients were subjected to routine laboratory investigations and clinical assessment and ultra -sonographic assessment. This study results concluded that there is a positive associationof IL 10 with occult HBV patients with ESRD undergoing regular HD.This resultgoes with the widespread suppression of immune responsesproduced by this cytokine.