Osteoporosis and Chronic Liver Diseases

Abstract

Metabolic bone diseases in the form of osteoporosis are important complication of chronic liver disease and many risk factors have been implicated in its development in such group of patients. From this point we designed our study to estimate prevalence of osteoporosis in patients with CLD and the relationship between variable risk factors and BMD in patients with CLD,that included 50 patients with CLD (35 males and 15 females) with Mean age 52.30 ± 12.47 years, and 20 healthy controls (6 males and 14 females) with Mean age 53.25 ± 8.43years. All patients underwent history taking and clinical examination. Laboratory investigations were done including AST, ALT, ALP, bilirubin,PT, albumin, Calcium and phosphorus, CBC, and radiological examination included X-ray of the thoraco-lumbar spine and abdominal ultrasound. BMI and BMD were measured for both patients and controls. Data were collected, tabulated and statistical analysis was done and revealed higher frequency of osteoporosis among patients with CLD 48% compared to control with only 5% had osteoporosis. We recorded,trabecular bones are affected more frequently and severely than cortical bones, (44% had osteoporosis at lumbar spine compared to 20% at femoral neck).