Innovation of a topical delivery system for lornoxicam

Abstract

Inflammation is a general, non-specific reaction to foreign particles and other noxious stimuli such as toxins and pathogens. It is the body's effort to inactivate or destroy invading organisms, remove irritants and set the stage for tissue repair. Characteristics of the inflammatory response include redness, swelling, pain and heat which are localized at the site of infection.

Inflammation may occur due to burns, chemical irritants, infection by pathogens, physical injury, immune reactions due to hypersensitivity, ionizing radiation and foreign bodies.

There are various types of burns, the most common are thermal burns which are caused by exposure to a heat source, chemical burns which are burns from an acid or lye compound and electrical burns from an electrical source. The size and severity of the burn usually determines the level of emergency represented by a particular incident.

Sunlight is composed of a continuous spectrum of electromagnetic radiation that is divided into three main regions of wavelengths: ultraviolet (UV), visible and infrared. UV radiation (UVR) comprises the wavelengths from 200 to 400 nm, the span of wavelengths just shorter than those of visible

light (400-700 nm). UV radiation is further divided into three sections, each of which has distinct biological effects: UVA (320-400 nm), UVB (280-320 nm) and UVC (200-280 nm).