Role of Helico-Bacter Pylori In The Pathogenesis of Hyperemesis Gravidarum

Abstract

A small percentage of pregnant women experience a severe form of nausea and vomiting that is termed hyperemesis gravidarum (synonym: excessive vomiting during pregnancy). This disorder has an estimated incidence of 0.5% - 2% of all live births. Little is known about the etiology of hyperemesis gravidarum, but a variety of mechanisms have been proposed as possible underlying causes. H. pylori which is a gram negative, flagellated bacterium has been recognized to play a role in diseases of the gastrointestinal tract. It has been hypothesized that H. pylori may increase the risk of hyperemesis gravidarum. This work is aimed at assessing the possible relation between H. Pylori infection and hyperemesis gravidarum. This study included 90 pregnant women between the gestational age from 8 weeks to 16 weeks who are attending obstetric clinic in Ain Shams maternity hospital. These women have been divided to two groups according to the presence or absence of hyperemesis gravidarum: group A; 45 patients (hyperemetic group) group B; 45 women(non hyperemetic group). The two groups were subjected to the following: - Full history taking - Clinical examination Lab investigations(complete blood count, AST, ALT, BUN, serum creatinine, fT3, fT4 and TSH, Na, K) Ultrasound assessing fetal life, gestational age and excluding gestational trophobastic diseases and multiple gestation.