COMPARATIVE STUDY ON THE EFFECT OF SMOKING ON DEPOLARIZING AND NON-DEPOLARIZING MUSCLE BLOCKADE UNDER ANESTHESIA
Sherif Samir Wahba;
Abstract
Despite the known actions of nicotine at the acetylcholine receptors of the neuromuscular junction, the response to
. neuromuscular blocking agents has not been assessed for influence of chronic exposure to nicotine from smoking.
This study compared onset time, duration of action, consumption, recovery and hemodynamic changes between smokers and non-smokers using both depolarizing and non-depolarizing
• neuromuscular blocking agents.
Three-hundred patients of both sexes aged 25 - 50 years scheduled for elective surgical procedures were included in this study. They were divided into three groups (non-smokers, cigarette smokers • and shesha smokers) and each group was further subdivided into five subgroups.
After premedication, anesthesia was induced with fentanyl and thiopentone and a control of neuromuscular response was obtained in all groups followed by injection of the neuromuscular blocking agent to facilitate endotracheal intubation. Anesthesia was maintained by 50% N20 in 02 with controlled ventilation using halothane 0.5- 1%.
The onset time was significantly shorter with atracurium in smokers and longer in vecuronium, pancuronium, rocuronium and succinylcholine while duration of action was significantly longer with atracurium in smokers but shorter in vecuromum, pancuronium, and rocuronium.
. neuromuscular blocking agents has not been assessed for influence of chronic exposure to nicotine from smoking.
This study compared onset time, duration of action, consumption, recovery and hemodynamic changes between smokers and non-smokers using both depolarizing and non-depolarizing
• neuromuscular blocking agents.
Three-hundred patients of both sexes aged 25 - 50 years scheduled for elective surgical procedures were included in this study. They were divided into three groups (non-smokers, cigarette smokers • and shesha smokers) and each group was further subdivided into five subgroups.
After premedication, anesthesia was induced with fentanyl and thiopentone and a control of neuromuscular response was obtained in all groups followed by injection of the neuromuscular blocking agent to facilitate endotracheal intubation. Anesthesia was maintained by 50% N20 in 02 with controlled ventilation using halothane 0.5- 1%.
The onset time was significantly shorter with atracurium in smokers and longer in vecuronium, pancuronium, rocuronium and succinylcholine while duration of action was significantly longer with atracurium in smokers but shorter in vecuromum, pancuronium, and rocuronium.
Other data
| Title | COMPARATIVE STUDY ON THE EFFECT OF SMOKING ON DEPOLARIZING AND NON-DEPOLARIZING MUSCLE BLOCKADE UNDER ANESTHESIA | Other Titles | دراسة مقارنة بين تأثير التدخين على مرخيات العضلات المستقطبة وغير المستقطبة | Authors | Sherif Samir Wahba | Issue Date | 2001 |
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