Synthesis of some Heterocyclic Compounds Containing Nitrogen With expected biological activity

Abstract

A new series of 6-aryl-5-cyano thiouracil derivatives were synthesized. Cyanouracil 4 was condensed with monochloroacetic acid and different aldehydes to give thiazolopyrimidine 5(a-h). On the other hand, treatment of cyanouracil 4 with 2-chloro-N-substituted-phenylacetamide afforded pyrimidine derivatives 7(a-c). N-alkylation of 4 with p-toluene sulfonyl chloride produced 6-(4-methoxyphenyl)-4-oxo-2-thioxo-1-tosyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (8). Mannich reaction of 4 with sulphanilamide and formaldehyde afforded (9) (Scheme 1).