THE COMBINED EFFECT OF NOISE AND AMINOGLYCOSIDE ANTIBIOTIC EXPOSURE ON THE AUDITORY SYSTEM OF THE FULL-TERM INFANT
Hala Zaki Ibrahem;
Abstract
SUMMARY
A
dequate hearing is critical for the speech and language acquisition allowing the child's social, psychic and educational development. Furthermore, early detection of hearing impairment is considered an essential factor for better results in the therapeutic process.
Hearing loss occurs in 2%-15%of pre-term infants, versus 0.1%-0.3% in full-term infants. It is hypothesized that the combination of ototoxic exposures, such as noise and aminoglycosides experienced in the NICU may explain much of this incidence.
This study aimed to examine the impact of aminoglycosides antibiotics and/or noise exposure on neonatal hearing screening outcome.
This study was conducted on 200 newborns from healthy infant screened at audiology clinic, Ain Shams University and others admitted at Neonatal Intensive Care Unit, Ain Shams University. Patients were recruited from January 2012 to April 2013.
One hundred and fifty patients were included in case group. They were exposed to noise and/or aminoglycosides risk factors. They were recruited from admitted newborns in NICU. Another fifty newborns were recruited from healthy infants screened at Audiology clinic and were not exposed to noise nor aminoglycosides. The newborns were classified according to exposure to noise and/or aminoglycosides into four groups. And as regard to pass and refer (fail) into two groups.
All newborn infants were subjected to complete history taking, clinical evaluation, laboratory investigations and testing of hearing by ABR.
On comparing the results of aABR hearing evaluation of the targeted screening groups with those of the control group, the at-risk groups were found to have higher percentages of failed results than those of the well-baby populations. The fact that 2% (1/50) of newborns who failed aABR tests were in the well-baby population further supports the necessity of universal hearing screening instead of selective screening in neonatal intensive care units, even with the obvious impact on cost-effectiveness.
Our study reported that the use of aminoglycosides ototoxic medication is an important risk factor of hearing loss in the neonatal period. Aminoglycoside antibiotics increased the probability of hearing loss when administered for seven days or more.
Noise exposure that had been generated by mechanical ventilators and monitors considered a risk factor for hearing loss for neonates admitted at NICU.
A
dequate hearing is critical for the speech and language acquisition allowing the child's social, psychic and educational development. Furthermore, early detection of hearing impairment is considered an essential factor for better results in the therapeutic process.
Hearing loss occurs in 2%-15%of pre-term infants, versus 0.1%-0.3% in full-term infants. It is hypothesized that the combination of ototoxic exposures, such as noise and aminoglycosides experienced in the NICU may explain much of this incidence.
This study aimed to examine the impact of aminoglycosides antibiotics and/or noise exposure on neonatal hearing screening outcome.
This study was conducted on 200 newborns from healthy infant screened at audiology clinic, Ain Shams University and others admitted at Neonatal Intensive Care Unit, Ain Shams University. Patients were recruited from January 2012 to April 2013.
One hundred and fifty patients were included in case group. They were exposed to noise and/or aminoglycosides risk factors. They were recruited from admitted newborns in NICU. Another fifty newborns were recruited from healthy infants screened at Audiology clinic and were not exposed to noise nor aminoglycosides. The newborns were classified according to exposure to noise and/or aminoglycosides into four groups. And as regard to pass and refer (fail) into two groups.
All newborn infants were subjected to complete history taking, clinical evaluation, laboratory investigations and testing of hearing by ABR.
On comparing the results of aABR hearing evaluation of the targeted screening groups with those of the control group, the at-risk groups were found to have higher percentages of failed results than those of the well-baby populations. The fact that 2% (1/50) of newborns who failed aABR tests were in the well-baby population further supports the necessity of universal hearing screening instead of selective screening in neonatal intensive care units, even with the obvious impact on cost-effectiveness.
Our study reported that the use of aminoglycosides ototoxic medication is an important risk factor of hearing loss in the neonatal period. Aminoglycoside antibiotics increased the probability of hearing loss when administered for seven days or more.
Noise exposure that had been generated by mechanical ventilators and monitors considered a risk factor for hearing loss for neonates admitted at NICU.
Other data
| Title | THE COMBINED EFFECT OF NOISE AND AMINOGLYCOSIDE ANTIBIOTIC EXPOSURE ON THE AUDITORY SYSTEM OF THE FULL-TERM INFANT | Other Titles | تاثيرالتعرض لكل من الضوضاء والمضاد الحيوى أمينوجليكوزيد على الجهاز السمعي لحديثى ا لولادة مكتملى العمر الرحمى | Authors | Hala Zaki Ibrahem | Issue Date | 2014 |
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