THE POTENTIAL EFFECT OF SILVER AND GOLD NANOPARTICLES AS MOLLUSCICIDES AND CERCARICIDES ON SCHISTOSOMA MANSONI
Eman Mohammad El-Sayed Hassan;
Abstract
Schistosomiasis is the second most prevalent parasitic disease in the world after malaria, Egypt’s share of the burden is about 7.2 million patients. Although transmission has been greatly reduced in Egypt, evidence indicated that a non-integrated intervention strategy is still used and transmission of infection in high-risk areas in the Nile Delta remains uninterrupted calling for improved, more comprehensive control strategies.
The use of NPs in medical field has been increased due to their properties as ultra-small size, large surface area to mass ratio and being highly reactive. In this aspect, AgNPs were found the most effective against bacteria, viruses and eukaryotic microorganisms, while AuNPs can destroy cancer cells and bacteria like MRSA. They also proved potent effect on selected parasites.
Prevention of schistosomiasis is more important than treatment itself. There is an urge to search for a new drug which can be safer and more effective than previous ones.
The present study aimed to evaluate the potential effect of Ag and Au NPs on B. alexandrina snails and S. mansoni cercariae in vitro and to assess their effect on the infectivity of cercariae in vivo.
For serving the in vitro study, B. alexandrina snails, S. mansoni miracidia and cercariae were obtained from Medical Malacology Laboratory at TBRI.
The in vitro study included, dose-response studies for detection of the mortality for each of B. alexandrina snails and cercariae of S. mansoni and detection of infection rate of the snails.
The use of NPs in medical field has been increased due to their properties as ultra-small size, large surface area to mass ratio and being highly reactive. In this aspect, AgNPs were found the most effective against bacteria, viruses and eukaryotic microorganisms, while AuNPs can destroy cancer cells and bacteria like MRSA. They also proved potent effect on selected parasites.
Prevention of schistosomiasis is more important than treatment itself. There is an urge to search for a new drug which can be safer and more effective than previous ones.
The present study aimed to evaluate the potential effect of Ag and Au NPs on B. alexandrina snails and S. mansoni cercariae in vitro and to assess their effect on the infectivity of cercariae in vivo.
For serving the in vitro study, B. alexandrina snails, S. mansoni miracidia and cercariae were obtained from Medical Malacology Laboratory at TBRI.
The in vitro study included, dose-response studies for detection of the mortality for each of B. alexandrina snails and cercariae of S. mansoni and detection of infection rate of the snails.
Other data
| Title | THE POTENTIAL EFFECT OF SILVER AND GOLD NANOPARTICLES AS MOLLUSCICIDES AND CERCARICIDES ON SCHISTOSOMA MANSONI | Other Titles | التأثير المحتمل لجزيئات الذهب والفضة النانوية علي قواقع وسركاريا دودة البلهارسيا المعوية | Authors | Eman Mohammad El-Sayed Hassan | Issue Date | 2017 |
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