AGE-RELATED CHANGES IN HEMOSTATIC RESPONSES TO STRESS IN RATS
ABDEL-HAMID ABOUEL-MAGD MOHAMED;
Abstract
In the present work , age-related changes in hemostatic responses to stress in rats were investigated and also , the effects of vitamin E supplementation , prior to stress induction on the hemostatic responses of those stressed rats were evaluated .
Two different models of stress were induced in rats which are:
1-Localized cold-induced stress : by keeping rat sole in
constant contact with iced-floor cages for 1 hour (acute localized cold-induced stress) or for 3 hours daily for 15 days (chronic localized cold stress).
2-Hydrogen peroxide (H202)-induced oxidative stress : by supplying rats with freshly prepared 3% solution ofH202 for 21 days.
The study was performed on male albino rats which were divided into the following groups :
!-Normal rat group : which was further subdivided into 3 groups according to their age :
a)Young mature rats (4 months) , weighing 60- 80
gm.
b)Middle-aged rats (14 months) weighing 180-220
gm.
c)Oid rats (24 months), weighing 270-350 gm.
2-Acute localized cold stress group .
3-Chronic localized cold stress group .
4-H20rinduced oxidative stress group .
Two different models of stress were induced in rats which are:
1-Localized cold-induced stress : by keeping rat sole in
constant contact with iced-floor cages for 1 hour (acute localized cold-induced stress) or for 3 hours daily for 15 days (chronic localized cold stress).
2-Hydrogen peroxide (H202)-induced oxidative stress : by supplying rats with freshly prepared 3% solution ofH202 for 21 days.
The study was performed on male albino rats which were divided into the following groups :
!-Normal rat group : which was further subdivided into 3 groups according to their age :
a)Young mature rats (4 months) , weighing 60- 80
gm.
b)Middle-aged rats (14 months) weighing 180-220
gm.
c)Oid rats (24 months), weighing 270-350 gm.
2-Acute localized cold stress group .
3-Chronic localized cold stress group .
4-H20rinduced oxidative stress group .
Other data
| Title | AGE-RELATED CHANGES IN HEMOSTATIC RESPONSES TO STRESS IN RATS | Other Titles | تأثير التقدم فى العمر على آلية إيقاف النزف فى الفئران المعرضة للتوتر | Authors | ABDEL-HAMID ABOUEL-MAGD MOHAMED | Issue Date | 2001 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.