Interventricular cardiac septal thickness in fetus of diabetic mother correlated to postnatal outcome
Heba Mohamed El Sayed;
Abstract
Diabetes mellitus still represents an important medical problem during pregnancy, causing perinatal morbidity, mortality, spontaneous abortion, stillbirth and congenital malformations despite improved outcome reflected by a steep decline in perinatal mortality over the past few decades, controversy still exists regarding the care of the pregnant woman with both pre-existing and gestational Diabetes Mellitus.
Hypertrophic cardiomyopathy found in infants who are born to diabetic mothers, is mainly related to the poor glycemic control of maternal diabetes and, consequently to fetal and neonatal hyperinsulinaemia.
Diabetic fetal cardiomyopathy causes symptoms in 5% but often transient, with no apparent lasting con-sequences for most infants.
Some infants of poorly controlled diabetic mothers experience significant complications from impaired cardiac function, such as congestive cardiac failure.
A characteristic feature of hypertrophic cardiomyopathy in infants of diabetic mothers is hy-pertrophy of the ventricular and septal walls. Cardiac hypertrophy is transient with spontaneously echocardiographic resolution within the first months after birth, irrespective of therapy.
Hypertrophic cardiomyopathy requires specific man-agement as digoxin and inotropic agents usually used in heart failure are contraindicated.
This study aim to study Interventricular septal thickness in fetus of diabetic mother and correlate it with good glycemic control. And to correlate postnatal cardiac function to Interventricular septal thickness to reach cut off value of septal thickness for prenatal prediction of symptomatic cardiomyopathy in infant of diabetic mother.
This study carried out on 120 diabetic pregnant ladies attending to antenatal care clinic or in patient in Aim Shames University Hospital. The study was carried out on 120 pregnant women of comparable age and parity. All were singleton pregnancies of 35 weeks or more. All cases were subjected to history taking and thorough physical examination. They were also subjected to ultrasonographic examination for fetal biometric parameters and for echo examination, the Apgar score of the newborn was assessed, the body weight was measured and the fetus was followed up for any complications.
Infants of diabetic mother with poor glycemic control showed significantly higher mean pre and post natal Interventricular septum thickness, right and left myocardial thickness and lower mean Ejection Fraction than those of mother with good control.
On comparing the difference between pre and post natal IVS in infants with mother of controlled diabetes and those with poor control: it showed higher difference in those of uncontrolled diabetic mothers when compared to infants of controlled diabetic mothers
Hypertrophic cardiomyopathy found in infants who are born to diabetic mothers, is mainly related to the poor glycemic control of maternal diabetes and, consequently to fetal and neonatal hyperinsulinaemia.
Diabetic fetal cardiomyopathy causes symptoms in 5% but often transient, with no apparent lasting con-sequences for most infants.
Some infants of poorly controlled diabetic mothers experience significant complications from impaired cardiac function, such as congestive cardiac failure.
A characteristic feature of hypertrophic cardiomyopathy in infants of diabetic mothers is hy-pertrophy of the ventricular and septal walls. Cardiac hypertrophy is transient with spontaneously echocardiographic resolution within the first months after birth, irrespective of therapy.
Hypertrophic cardiomyopathy requires specific man-agement as digoxin and inotropic agents usually used in heart failure are contraindicated.
This study aim to study Interventricular septal thickness in fetus of diabetic mother and correlate it with good glycemic control. And to correlate postnatal cardiac function to Interventricular septal thickness to reach cut off value of septal thickness for prenatal prediction of symptomatic cardiomyopathy in infant of diabetic mother.
This study carried out on 120 diabetic pregnant ladies attending to antenatal care clinic or in patient in Aim Shames University Hospital. The study was carried out on 120 pregnant women of comparable age and parity. All were singleton pregnancies of 35 weeks or more. All cases were subjected to history taking and thorough physical examination. They were also subjected to ultrasonographic examination for fetal biometric parameters and for echo examination, the Apgar score of the newborn was assessed, the body weight was measured and the fetus was followed up for any complications.
Infants of diabetic mother with poor glycemic control showed significantly higher mean pre and post natal Interventricular septum thickness, right and left myocardial thickness and lower mean Ejection Fraction than those of mother with good control.
On comparing the difference between pre and post natal IVS in infants with mother of controlled diabetes and those with poor control: it showed higher difference in those of uncontrolled diabetic mothers when compared to infants of controlled diabetic mothers
Other data
| Title | Interventricular cardiac septal thickness in fetus of diabetic mother correlated to postnatal outcome | Other Titles | سماكه الحاجز القلبي لجنين إلام المصابة بمرض السكر وتأثيره على وظيفية القلب بعد الولادة | Authors | Heba Mohamed El Sayed | Issue Date | 2014 |
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