Study of the Role of Somatostatin and Insulin in Haemodialysis-induced Hypoglycaemia in Non­ diabetic Patients with Chronic renal failure.

Abstract

Patients on maintenance liD with glucose-free dialysate are at risk of developing significant hypoglycemia during liD, being unable to respond to it and being unaware of it. This may be a consequence of their regular episodes of liD producing repeated episodes of hypoglycemia. This situation was described as occult or hidden hypoglycemia.

The objective of this study was to estimate the levels of serum insulin and plasma somatostatin during OGTT and during hypoglycemia precipitated by glucose-free liD sessions.

The study was carried out on 20 nondiabetic patients on maintenance liD for at least 1 year. They were subdivided into 2 groups:

Group I (a): included 10 patients on acetate HD. They were 6 males and 4 females aged 39-67 years.

Group I (b): included 10 patients on bicarbonate HD. They were 5 males and 5 females aged 28-70 years.

Group II: included 10 healthy subjects of matching age and sex served as a control group (group II).

The results of the present study showed that there was significant hypoglycemia during glucose-free HD.

Patients showed OGTT comparable to that of control subjects.