Assessment Of Serum Macrophage Inflammatory Protein -1- a. In Pediatric Patients With Bone Marrow Aplasia
Dina Ahmed Ezzat Taher;
Abstract
This study confirm the role of marrow microenvironment in the pathogenesis of bone marrow failure.
Macrophage inflammatory protein-1-a play an important pathogenetic role in bone marrow failure, smce its serum level is higher in BMF patients than control groups.
This chemokine can be an adding diagnostic test to differentiate between acquired aplastic anemia and Fanconi anemia not associated with the characteristic morphological features.
Some bone marrow failure patients either AAA or FA who are considered to be responders to treatment by the different clinical and hematological parameters, showed that MIP-1- a level is still high, not returning to normal levels.
A careful and long duration of wise follow up is needed for such patients who still have ongoing immune-dysfunction to prevent exacerbation of the disease that might occur at any time.
Macrophage inflammatory protein-1-a play an important pathogenetic role in bone marrow failure, smce its serum level is higher in BMF patients than control groups.
This chemokine can be an adding diagnostic test to differentiate between acquired aplastic anemia and Fanconi anemia not associated with the characteristic morphological features.
Some bone marrow failure patients either AAA or FA who are considered to be responders to treatment by the different clinical and hematological parameters, showed that MIP-1- a level is still high, not returning to normal levels.
A careful and long duration of wise follow up is needed for such patients who still have ongoing immune-dysfunction to prevent exacerbation of the disease that might occur at any time.
Other data
| Title | Assessment Of Serum Macrophage Inflammatory Protein -1- a. In Pediatric Patients With Bone Marrow Aplasia | Other Titles | قياس نسبة بروتين الخلايا الالتهامية وان - الفا فى الاطفال المصابين بأمراض فشل نخاع العظام | Authors | Dina Ahmed Ezzat Taher | Issue Date | 2002 |
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