Assessment of D-Dimer and Protein S in Egyptian Cirrhotic Patients with and without Ascites

Abstract

Liver cirrhosis is a chronic disease associated with complications, ascites as a complication of liver cirrhosis plays a major role in the pathogenesis of hyperfibrenolytic state associated with liver failure. This study was carried out on 90 patients with liver cirrhosis as well as 10 control healthy volunteer, the 90 patients were classified according to the severity of liver disease based on Child-Pugh class into three groups. Group I (30 patients with Child-Pugh class A) , group II (30 patients with Child-Pugh class B), group III (30 patients with Child-Pugh class C), they were furtherly subdivided according to presence or absence of ascites in each individual group . The studied cases were subjected to proper history taking, complete clinical examination, abdominal ultrasonography, the laboratory assessment included complete blood picture, liver function tests, hemostatic parameters; D-Dimer levels, and Protein S activity. The results showed significant increase of Plasma D-Dimer levels, and significant reduction of Protein S activity in cirrhotic patients when compared with the control group (P<0.001), their Plasma levels were correlated with other