Modulation of doxorubicin induced neurotoxicity by astaxanthin in experimental rat model

Abstract

Doxorubicin (DOX) is a prominent mainstay member of the anthracycline antineoplastic agents. It is one of the most potent FDA-approved agents for treatment of solid tumors and hematological malignancies. The mechanism underlying DOX-induced chemobrain is thought to be cytokine-induced oxidative and nitrosative damage to brain tissues. Astaxanthin (AST), a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti-inflammatory and antiapoptotic activities. Therefore, the aim of the current study was to experiment DOX-induced cognitive deficits rodent model, determine the neuroprotective dose of AST against DOX-induced behavioral and neurobiological abnormalities and elucidate the underlying